{"id":15164,"date":"2021-09-02T07:47:15","date_gmt":"2021-09-02T05:47:15","guid":{"rendered":"https:\/\/ctt.uwr.edu.pl\/koniugat\/"},"modified":"2022-01-26T12:10:41","modified_gmt":"2022-01-26T11:10:41","slug":"koniugat","status":"publish","type":"page","link":"https:\/\/ctt.uwr.edu.pl\/en\/koniugat\/","title":{"rendered":"Koniugat"},"content":{"rendered":"\n<div class=\"wp-block-columns bs-news-page is-layout-flex wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column bs-kontakt-photo is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/ctt.uwr.edu.pl\/wp-content\/uploads\/sites\/8\/2021\/05\/DSC01122-1024x683.jpg\" alt=\"\"\/><\/figure>\n\n\n\n<p class=\"has-normal-font-size wp-block-paragraph\"><strong>Pat.227502<\/strong> New conjugate fibroblast growth factor, a method for its preparation and application<br><strong>Inventors:<\/strong> Anna Szlachcic, Katarzyna Pala, Ma\u0142gorzata Zakrzewska, Piotr Jakimowicz, Jacek Otlewski<\/p>\n\n\n\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-7a35bd4\" data-block-id=\"7a35bd4\"><div class=\"stk-row stk-inner-blocks has-text-align-center stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-button stk-block-button is-style-ghost stk-block stk-7f8927d\" data-block-id=\"7f8927d\"><style>.stk-7f8927d .stk-button{background:transparent !important}.stk-7f8927d .stk-button:hover:after{background:transparent !important;opacity:1 !important}:where(.stk-hover-parent:hover,.stk-hover-parent.stk--is-hovered) .stk-7f8927d .stk-button:after{background:transparent !important;opacity:1 !important}.stk-7f8927d .stk-button:before{border-style:solid !important}<\/style><a class=\"stk-link stk-button stk--hover-effect-scale-more\" href=\"https:\/\/api-ewyszukiwarka.pue.uprp.gov.pl\/api\/collection\/662f5437b71ccc89985e747532c5414a\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk-button__inner-text\">Patent description in Polish<\/span><\/a><\/div>\n\n\n\n<div class=\"wp-block-stackable-button stk-block-button is-style-ghost stk-block stk-4fb1253\" data-block-id=\"4fb1253\"><style>.stk-4fb1253 .stk-button{background:transparent !important}.stk-4fb1253 .stk-button:hover:after{background:transparent !important;opacity:1 !important}:where(.stk-hover-parent:hover,.stk-hover-parent.stk--is-hovered) .stk-4fb1253 .stk-button:after{background:transparent !important;opacity:1 !important}.stk-4fb1253 .stk-button:before{border-style:solid !important}<\/style><a class=\"stk-link stk-button stk--hover-effect-scale-more\" href=\"https:\/\/ctt.uwr.edu.pl\/kontakt\/?lang=en\" rel=\"noreferrer noopener\"><span class=\"stk-button__inner-text\">Contact us<\/span><\/a><\/div>\n<\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column bs-contact-right-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-bonasoft-modular-breadcrumbs-block\"><div class=\"bs_add_breadcrumb_trail\"><\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-background has-black-background-color has-black-color is-style-wide bs-border-kontakt\"\/>\n\n\n\n<h1 class=\"bs-naglowek-podstrony wp-block-heading\"><strong><strong><strong>New conjugate fibroblast growth factor FGF1 <\/strong><\/strong><\/strong><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">Cytostatic agents are a group of drugs used in the cancer treatment. Unfortunately, many of them are highly cytotoxic and cannot be used alone due to their harmful systemic effects and causing a wide range of side effects. The latest cancer treatments are mostly based on targeted therapies, which use specific proteins on the surface of cancer cells that are absent (or present in significantly smaller amounts) in healthy cells. Their use enables more selective and effective distribution of the drug to the affected area. However, this is not an ideal system; antibodies are relatively large, which makes their modification difficult. Moreover, they often show affinity to more than one molecular target, thus reducing the specificity of therapy. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In the Department of Protein Engineering at the Faculty of Biotechnology, under the leadership of Professor Jacek Otlewski, an alternative method of drug delivery to tumour cells has been developed using a conjugate of a mutated variant of fibroblastic growth factor FGF1. Increased expression of fibroblastic growth factor receptors has been observed in many cancers, including breast, prostate, bladder, as well as in lung cancer. The use of specific ligands for FGF receptors creates an opportunity to develop diagnostic or therapeutic methods in these tumours. Growth factors are highly selective and, in addition, are smaller in size than antibodies, which means that they may have greater potential as targeting molecules than immunoglobulins.<\/p>\n<\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pat.227502 New conjugate fibroblast growth factor, a method for its preparation and applicationInventors: Anna Szlachcic, Katarzyna Pala, Ma\u0142gorzata Zakrzewska, Piotr Jakimowicz, Jacek Otlewski Patent description in Polish Contact us New conjugate fibroblast growth factor FGF1 Cytostatic agents are a group of drugs used in the cancer treatment. Unfortunately, many of them are highly cytotoxic and [&hellip;]<\/p>\n","protected":false},"author":39,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[],"tags":[],"class_list":["post-15164","page","type-page","status-publish","hentry"],"featured_image_urls_v2":{"full":"","thumbnail":"","medium":"","medium_large":"","large":"","1536x1536":"","2048x2048":"","menu-24x24":"","menu-36x36":"","menu-48x48":""},"post_excerpt_stackable_v2":"<p>Pat.227502 New conjugate fibroblast growth factor, a method for its preparation and applicationInventors: Anna Szlachcic, Katarzyna Pala, Ma\u0142gorzata Zakrzewska, Piotr Jakimowicz, Jacek Otlewski Patent description in Polish Contact us New conjugate fibroblast growth factor FGF1 Cytostatic agents are a group of drugs used in the cancer treatment. Unfortunately, many of them are highly cytotoxic and cannot be used alone due to their harmful systemic effects and causing a wide range of side effects. The latest cancer treatments are mostly based on targeted therapies, which use specific proteins on the surface of cancer cells that are absent (or present in significantly&hellip;<\/p>\n","category_list_v2":"Uncategorized","author_info_v2":{"name":"jczeszejko","url":"https:\/\/ctt.uwr.edu.pl\/en\/author\/jczeszejko\/"},"comments_num_v2":"0 comments","acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Koniugat - Centrum Transferu Technologii<\/title>\n<meta name=\"description\" content=\"CTT jest jednostk\u0105 og\u00f3lnouczelnian\u0105, powo\u0142an\u0105 w celu wsparcia potencja\u0142u naukowego i technologicznego UWr oraz transferu wynik\u00f3w naukowych do gospodarki.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ctt.uwr.edu.pl\/koniugat\/?lang=en\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Koniugat - 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